Aside its record-breaking attendance record, the event is arguably best remembered for "The Ultimate Challenge" - the main event match which saw Hulk Hogan (WWF Champion) vs The Ultimate Warrior (WWF Intercontinental Champion), in which both championship titles were on the line. On February 3, 1990, a week after Hogan and Warrior crossed paths in the 1990 Royal Rumble Match, Hogan put forth "The Ultimate Challenge" to the Warrior, and had to know whether Hulkamania or the power of the Warrior was the strongest force in the World Wrestling Federation. On February 10th, the match was officially announced as the main event of WrestleMania VI by WWF President Jack Tunney. On February 24th, Tunney announced that both the WWF Championship and Intercontinental Championship would be on the line for the first-time ever during the match.
At WrestleMania VI, Brutus "The Barber" Beefcake was the first person to pin Mr. Perfect in a televised match, thus ending Perfect's lengthy undefeated streak "the perfect record" in most fans' eyes.
André the Giant appeared in his final televised match at Wrestlemania VI. This was Dusty Rhodes' only Wrestlemania match. This was Rick Rude's final Wrestlemania match. This was Bad News Brown's final Wrestlemania match. This was Akeem's final Wrestlemania match for 11 years where he would return as The One Man Gang at WrestleMania X-Seven. This was the Orient Express' only Wrestlemania match.