The September 28, 2000 Edition of Smackdown is a Professional wrestling television show of the WWF's Smackdown brand, which took place on September 26, 2000 at Mellon Arena in Pittsburgh, Pennsylvania.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- WWF World Women's Title Match: Lita (w/ Jeff Hardy & Matt Hardy) (c) defeated Jacqueline (w/ Christian & Edge) (2:35)
- WWF Hardcore Title Match: Steve Blackman (c) defeated The Road Dogg (5:27)
- Six Man Tag Team Match: Rikishi & Too Cool (Grandmaster Sexay & Scotty 2 Hotty) (w/ Mandy & Victoria) defeated Kane & T&A (Albert & Test) (w/ Trish Stratus) (5:19)
- Tag Team Match: Raven & Tazz defeated Chris Jericho & Jerry Lawler (3:27)
- Singles Match: Chyna (w/ Eddie Guerrero) defeated Steven Richards (w/ Val Venis) (3:16)
- WWF European Title Match: Al Snow (c) vs. X-Pac - No Contest (1:58)
- Tag Team Match: Chris Benoit & Kurt Angle defeated The Rock & Triple H (w/ Stephanie McMahon-Helmsley) (9:27)