The September 24, 2010 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took take place on September 21, 2010 at the U.S. Cellular Coliseum in Bloomington, Illinois.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Kane defeated Chris Masters (6:00)
- Cody Rhodes & Drew McIntyre (c) defeated The Hart Dynasty (David Hart Smith & Tyson Kidd) (w/Natalya) to retain the WWE Tag Team Title (7:30)
- Chavo Guerrero defeated Kaval (4:30)
- The Big Show defeated Curt Hawkins & Vance Archer in a Two On One Handicap Match (1:10)
- CM Punk defeated Luke Gallows (3:30)
- Montel Vontavious Porter defeated Dolph Ziggler by Countout (11:35)
- Dark Match: The Undertaker defeated Kane (c) by DQ in a World Heavyweight Championship Match
- WWE Smackdown #579 at CAGEMATCH.net
- [Smackdown #579 on WWE Network]