The September 22, 2006 Edition of Smackdown is a Professional wrestling television show of the WWE, which took place at the Bell Centre in Montreal, Quebec, Canada. It was taped on September 18, 2006.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Batista & Bobby Lashley defeated Finlay & William Regal (7:33)
- Matt Hardy defeated Gregory Helms (5:42)
- The Miz defeated Funaki (2:36)
- Chavo Guerrero (w/ Vickie Guerrero) vs. Rey Mysterio ended in a no contest in a street fight (4:43)
- Brian Kendrick & Paul London (c) defeated Idol Stevens & KC James (w/ Michelle McCool) and The Pitbulls (Jamie Noble & Kid Kash) in a Triple Threat Match to retain the WWE Tag Team Championship (5:40)
- Sylvan defeated Tatanka (3:41)
- The Undertaker defeated King Booker (w/ Queen Sharmell) by DQ (12:13)