|Friday Night Smackdown|
|Date||September 21, 2000|
|Previous episode||September 14, 2000|
|Next episode||September 28, 2000|
The September 21, 2000 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took place on September 19, 2000 at the Bradley Center in Milwaukee, Wisconsin.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- The APA (Bradshaw & Faarooq) defeated The Right To Censor (Bull Buchanan & The Good Father) (w/ Steven Richards & Val Venis) (0:48)
- Six Man Tag Team Match: The Rock, The Undertaker & Triple H (w/ Stephanie McMahon-Helmsley) defeated Chris Benoit, Kane & Kurt Angle (9:13)
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