The September 18, 2009 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took place on September 15, 2009 at the Copps Coliseum in Hamilton, Ontario.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Non Title Match: John Morrison defeated Mike Knox (7:55)
- Non Title Match: Melina defeated Michelle McCool (4:18)
- Tag Team Match: The Hart Dynasty (David Hart Smith & Tyson Kidd) (w / Natalya) defeated Cryme Tyme (JTG & Shad Gaspard) (w / Eve Torres) (11:50)
- Singles Match: The Great Khali (w / Ranjin Singh) defeated Kane by DQ (0:45)
- Singles Match: Batista defeated Chris Jericho (6:27)
- Dark World Heavyweight Title Match: CM Punk (c) defeated The Undertaker by DQ
- Smackdown #526
- [Smackdown #526 on WWE Network]