The September 17, 2010 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took place on September 14, 2010 at the Joe Louis Arena in Detroit, Michigan.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Dark Match: Tyler Reks defeated Trent Baretta
- Cody Rhodes & Drew McIntyre defeated The Hart Dynasty (David Hart Smith & Tyson Kidd) (w/ Natalya) (11:15)
- Kofi Kingston defeated Jack Swagger (16:20)
- Team Lay-Cool (Layla & Michelle McCool) (w/ Kaval) defeated Kelly Kelly & Rosa Mendes (w/ Naomi) (2:00)
- CM Punk defeated Christian (12:00)
- Dark Match: The Undertaker defeated Kane (c) by Count Out in a World Heavyweight Championship Match
- WWE Smackdown #578 at CAGEMATCH.net
- [Smackdown #578 on WWE Network]