The September 16, 2005 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took take place on September 12, 2005 at the Alltel Arena in Little Rock, Arkansas.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Christian & Orlando Jordan defeated Booker T & Chris Benoit (w/ Sharmell) (7:37)
- The Legion of Doom (Heidenreich & Road Warrior Animal) (c) defeated MNM (Mercury & Nitro) (w/ Melina) via DQ to retain the WWE Tag Team Championship (4:50)
- Rey Mysterio defeated John Bradshaw Layfield (6:42)
- Ken Kennedy defeated Jacus Plisken (1:03)
- Batista defeated Nunzio (w/ Vito) (2:54)
- The Undertaker defeated Randy Orton (18:35)