The September 15, 2006 Edition of Smackdown is a Professional wrestling television show of the WWE, which took place at the DCU Center in Worcester, Massachusetts. It was taped on September 12, 2006. This is the final SmackDown to air on UPN
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Dark Match: Sylvan defeated Scott Wright
- Gregory Helms defeated Matt Hardy (6:21)
- The Miz defeated Scotty 2 Hotty (4:51)
- Brian Kendrick (w/ Ashley & Paul London) defeated Idol Stevens (w/ KC James & Michelle McCool) and Kid Kash (w/ Jamie Noble) in a Triple Threat Match (3:10)
- Mr. Kennedy defeated Rey Mysterio (17:07)
- Vito defeated William Regal (4:58)
- Sylvester Terkay (w/ Elijah Burke) defeated Todd Smith (2:34)
- Bobby Lashley defeated Finlay (w/ King Booker, Queen Sharmell & William Regal) by DQ in a World Heavyweight Title #1 Contendership Match (13:15)
- Smackdown #370
- [Smackdown #370 on WWE Network]