The September 14, 2007 Edition of Smackdown is a Professional wrestling television show of the WWE, which took place at the Target Center in Minneapolis, Minnesota. It was taped on September 11, 2007.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Dark Tag Team Match: Festus & Jesse defeated ? & ?
- Dark Match: Jimmy Wang Yang defeated KC James
- Singles Match: Michelle McCool (w/ Chuck Palumbo) vs. Victoria (w/ Kenny Dykstra) ended in a No Contest
- Mixed Tag Team Match: Chuck Palumbo & Michelle McCool defeated Kenny Dykstra & Victoria (11:50)
- Singles Match: Shannon Moore defeated Jamie Noble (5:30)
- Singles Match: Domino (w/ Cherry & Deuce) defeated Montel Vontavious Porter (w/ Matt Hardy) (6:00)
- Belfast Brawl Match: Finlay defeated Kane (17:30)
- Non-Title Match: Batista defeated The Great Khali by DQ (4:05)
- Smackdown #421
- [Smackdown #421 on WWE Network]