The September 10, 2010 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took place on September 7, 2010 at the 1st Mariner Arena in Baltimore, Maryland.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Dark Match: JTG defeated Tyler Reks
- Jack Swagger defeated Montel Vontavious Porter (8:18)
- Alberto Del Rio defeated Matt Hardy (11:12)
- Drew McIntyre defeated Kaval (3:57)
- Chris Masters & Kofi Kingston defeated Chavo Guerrero & Dolph Ziggler (w/ Kaitlyn & Vickie Guerrero) (2:47)
- The Undertaker defeated CM Punk (14:10)
- Dark Match: Kane (c) vs. The Undertaker ended in a double count out in a World Heavyweight Championship