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The October 28, 2005 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took take place on October 25, 2005 at the Cow Palace in San Francisco, California.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Rey Mysterio defeated Christian, Hardcore Holly, John Bradshaw Layfield & Matt Hardy in a five-way match (8:54)
- Short Sleeve Sampson defeated Pitbull Patterson (2:28)
- MNM (Mercury & Nitro) (w/ Melina) defeated The Legion of Doom (Heidenreich & Road Warrior Animal) (c) and The Mexicools (Psicosis & Super Crazy) (w/ Juventud) and Paul Burchill & William Regal to win the WWE Tag Team Championship (11:45)
- Batista, Eddie Guerrero & Roddy Piper defeated Bob Orton, Jr., Mr. Kennedy & Randy Orton (10:26)