The October 22, 2010 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took take place on October 19, 2010 at the Rexall Place in Edmonton, Alberta, Canada.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Dark Match: Trent Baretta defeated Curt Hawkins
- Kofi Kingston, Rey Mysterio & The Big Show defeated Ezekiel Jackson, Sheamus & The Miz (8:40)
- Jack Swagger defeated Santino Marella (2:50)
- Alberto Del Rio defeated John Morrison (4:30)
- Kelly Kelly & Natalya defeated LayCool (Layla & Michelle McCool) (2:20)
- CM Punk vs. Edge Ended in a No Contest (13:15)
- Randy Orton defeated Kane (12:00)