The November 26, 2010 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took take place on November 23, 2010 at the Jacksonville Veterans Memorial Arena in Jacksonville, Florida
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Kofi Kingston defeated Jack Swagger in a King of the Ring qualifying match (17:20)
- Alberto Del Rio defeated The Big Show by Countout in a King of the Ring qualifying match (8:10)
- Drew McIntyre defeated Montel Vontavious Porter in a King of the Ring qualifying match (5:20)
- Kelly Kelly defeated Michelle McCool (w/ Layla) (1::02)
- Cody Rhodes defeated Rey Mysterio in a King of the Ring qualifying match (8:20)
- Dark Match: Rey Mysterio & Big Show defeated Alberto Del Rio & Drew McIntyre
- WWE Smackdown #588 at CAGEMATCH.net
- [Smackdown #588 on WWE Network]