The November 12, 2010 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took take place on November 9, 2010 at the Manchester Evening News Arena in Manchester, England, UK.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Dark Match: Mason Ryan defeated Chavo Guerrero
- Alberto Del Rio defeated Kofi Kingston (11:30)
- Natalya defeated Layla (w/ Michelle McCool) (3:30)
- David Otunga defeated Edge in a Lumberjack match(10:00)
- Dolph Ziggler (c) defeated Montel Vontavious Porter to retain the WWE Intercontinental Championship (8:40)
- The Big Show defeated Kane (14:30)
- Dark Match: Edge & Rey Mysterio defeated Alberto Del Rio & Kane