NJPW Road To Destruction 2016 - Night 12 took place on September 21, 2016 at Niihama Citizien Gymnasium in Niihama, Ehime, Japan.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Roppongi Vice (Beretta & Rocky Romero) defeated Hirai Kawato & Teruaki Kanemitsu (10:18)
- Great Bash Heel (Togi Makabe & Tomoaki Honma), Captain New Japan & Yoshitatsu defeated TenKoji (Hiroyoshi Tenzan & Satoshi Kojima), Henare & Manabu Nakanishi (8:14)
- Chase Owens & Yujiro Takahashi defeated CHAOS (Gedo & Tomohiro Ishii) (10:10)
- Ryusuke Taguchi, Tiger Mask & Yuji Nagata defeated reDRagon (Bobby Fish & Kyle O'Reilly) & David Finlay (11:25)
- BULLET CLUB (Bad Luck Fale, Kenny Omega, Tama Tonga & Tanga Loa) defeated CHAOS]] (Hirooki Goto, Kazuchika Okada, Will Ospreay & YOSHI-HASHI) (11:30)
- Los Ingobernables de Japon (BUSHI, EVIL, SANADA & Tetsuya Naito) defeated Hiroshi Tanahashi, Juice Robinson, KUSHIDA & Michael Elgin (17:31)