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The May 7, 2010 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, took place on May 4, 2010 at the North Charleston Coliseum in North Charleston, South Carolina.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Dark Match: Gatecrashers (Curt Hawkins & Vance Archer) defeated Chasyn Rance & JT Talent
- Montel Vontavious Porter defeated Luke Gallows (w/ CM Punk & Serena) (4:00)
- Layla & Michelle McCool (w/ Vickie Guerrero) defeated Kelly Kelly & Tiffany (3:00)
- Kofi Kingston defeated Dolph Ziggler in a Intercontinental Title Tournament Semi Final Match (12:00)
- Christian defeated Cody Rhodes in a Intercontinental Title Tournament Semi Final Match (12:00)
- Kane defeated Jack Swagger by DQ (5:00)
- Dark Match: Jack Swagger (c) defeated The Big Show by DQ to retain the World Heavyweight Championship