The May 22, 2003 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which will take place on May 20, 2003 at the Greensboro Coliseum in Greensboro, North Carolina.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- WWE Tag Team Title Match: Eddie Guerrero & Tajiri (c) defeated Team Angle (Charlie Haas & Shelton Benjamin) by DQ (15:32)
- Lie Detector Test Vs. Piper's Job Match: Sean O'Haire (w / Roddy Piper) defeated Mr. America (w / Zach Gowen) (7:00)) by Count Out