The March 21, 2008 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, it was taped on March 18, 2008 at the Mississippi Coast Coliseum in Biloxi, Mississippi.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
Batista v Deuce and Domino
Diva Arm Wrestling contest
3-on-1 Handicap match
Edge v Funaki
John Morrison and The Miz v Jesse and Festus
The Undertaker v Chavo Guerrero
- WWE Smackdown #448 at CAGEMATCH.net
- [Smackdown #448 on WWE Network]