The February 24, 2006 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took take place on February 21, 2006 at the Richmond Coliseum in Richmond, Virginia.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- MNM (Mercury & Nitro) (c) (w/ Melina) defeated Matt Hardy & Tatanka to retain the WWE Tag Team Championship (7:23)
- The Boogeyman defeated The Dicks (Chad Dick & James Dick) in a Two On One Handicap Match (1:43)
- Gregory Helms (c) defeated Psicosis to retain the WWE Cruiserweight Championship (5:25)
- Bobby Lashley, Chris Benoit & Rey Mysterio defeated Finlay, John Bradshaw Layfield & Randy Orton (15:54)
- Dark Match: Kurt Angle (c) defeated Mark Henry, Randy Orton & The Undertaker in a Fatal Four Way Match to retain the World Heavyweight Championship
- Smackdown #341
- [Smackdown #341 on WWE Network]