The February 22, 2008 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, it was taped on February 19, 2008 at the San Diego Sports Arena in San Diego, California.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Jesse & Festusdefeated Deuce & Domino (w/ Cherry) (5:15)
- Big Daddy V (w/ Matt Striker) defeated Shannon Moore (3:10)
- Batista defeated Montel Vontavious Porter (7:41)
- Kane defeated The Great Khali (3:10)
- Chuck Palumbo defeated Matt Jackson (2:00)
- Rey Mysterio defeated Chavo Guerrero (w/ Vickie Guerrero & Teddy Long) (9:07)