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Destination X 2006 was a professional wrestling pay-per-view (PPV) event produced by Total Nonstop Action Wrestling (TNA), which took place on March 12, 2006 from the TNA Impact! Zone in Orlando, Florida. It was the second event under the Destination X chronology. Eight professional wrestling matches were featured on the event's card.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Pre-Show match: Shannon Moore defeated Cassidy Riley (3:21)
- Pre-Show match: The Diamonds in the Rough (David Young and Elix Skipper) (w/ Simon Diamond) defeated Shark Boy and Norman Smiley (3:17)
- Alex Shelley defeated Jay Lethal (10:08)
- Lance Hoyt defeated Matt Bentley (with Traci) (7:59)
- Team Canada (Bobby Roode and Eric Young) (with Coach D'Amore and A-1) defeated The Naturals (Chase Stevens and Andy Douglas) (12:24)
- The James Gang (B.G. James and Kip James) and Bob Armstrong defeated The Latin American Exchange (Konnan, Homicide and Machete) (6:38)
- Chris Sabin defeated Petey Williams (with A-1), Sonjay Dutt and Puma in a Four Way match (14:57)
- Jeff Jarrett, Abyss, and America's Most Wanted (Chris Harris and James Storm) (w/ James Mitchell and Gail Kim) defeated Rhino, Ron Killings, and Team 3D (Brother Ray and Brother Devon) in an 8-Man War (20:10)
- Christopher Daniels defeated Samoa Joe (c) and A.J. Styles in an Ultimate X match to win the TNA X Division Championship (13:26)
- Christian Cage (c) defeated Monty Brown to retain the NWA World Heavyweight Championship (17:11)
|2006 Total Nonstop Action Wrestling pay-per-views|
| Final Resolution • Against All Odds • Destination X • Lockdown • Sacrifice • Slammiversary|
Victory Road • Hard Justice • No Surrender • Bound for Glory • Genesis • Turning Point
|2005 • 2006 • 2007 • 2008 • 2009 • 2010 • 2011 • 2012 • 2013 • 2014|