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The December 31, 2010 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took take place on December 28, 2010 at the Blue Cross Arena in Rochester, New York.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Dark Match: Percy Watson defeated Curt Hawkins
- The Big Show defeated Cody Rhodes by count out (2:50)
- Drew McIntyre defeated Trent Baretta by referee decision (4:40)
- Edge & Rey Mysterio defeated Alberto Del Rio & Kane (12:45)
- Beth Phoenix & Natalya defeated LayCool (Layla & Michelle McCool) (9:40)
- Dolph Ziggler (w/ Vickie Guerrero) (c) defeated Jack Swagger and Kofi Kingston in a Triple Threat Match to retain the WWE Intercontinental Championship (16:15)