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The December 21, 2010 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took take place on December 21, 2010 at the AT&T Center in San Antonio, Texas. This episode was live on the USA Network, it's the first time Smackdown has aired live.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Dark Match: Trent Baretta defeated Abraham Washington
- Randy Orton defeated The Miz by DQ (13:52)
- Santino Marella (w/ Vladimir Kozlov) defeated Chavo Guerrero (2:54)
- Drew McIntyre defeated Kaval (0:26)
- Kofi Kingston & Rey Mysterio defeated Jack Swagger & Alberto Del Rio (13:40)
- John Cena defeated Dolph Ziggler & Vickie Guerrero in a 2 on 1 handicap match (13:30)
- Dark Match: Edge (c) defeated Kane to retain the World Heavyweight Championship