The December 17, 2010 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took take place on December 14, 2010 at the Cajundome in Lafayette, Louisiana.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Dark Match: Trent Baretta defeated Abraham Washington
- Kaval & Kofi Kingston defeated Dolph Ziggler & Jack Swagger (11:00)
- Cody Rhodes defeated Chris Masters (1:10)
- The Miz defeated Rey Mysterio (13:25)
- Santino Marella & Vladimir Kozlov defeated Chavo Guerrero & Tyler Reks (3:45)
- Edge & Rey Mysterio vs. Alberto Del Rio & The Miz ended in a no contest (7:30)
- Dark Match: Edge defeated Kane (c) by DQ for the World Heavyweight Championship
- WWE Smackdown #591 at CAGEMATCH.net
- [Smackdown #591 on WWE Network]