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Cape Girardeau; colloquially referred to as "Cape") is a city located in Cape Girardeau and Scott counties in Southeast Missouri in the United States. It is located approximately 115 miles (185 km) southeast of St. Louis and 175 miles (282 km) north of Memphis. As of the 2010 census, the city's population was 37,941. A college town, it is the home of Southeast Missouri State University. It is the largest city in southeast Missouri.

The Cape Girardeau-Jackson, MO-IL Metropolitan Statistical Area encompasses Alexander County, Illinois, Bollinger County, Missouri and Cape Girardeau County, Missouri.

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