The April 7, 2005 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, which took take place on April 5, 2005 at the San Diego Sports Arena in San Diego, California.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Paul London (c) defeated Billy Kidman to retain the WWE Cruiserweight Championship (6:14)
- The Big Show defeated Luther Reigns (2:13)
- Kurt Angle defeated Jose Macias in a Kurt Angle Invitational Challenge Match
- John Bradshaw Layfield (w/ Orlando Jordan) defeated Rey Mysterio by DQ in a WWE Heavyweight Title #1 Contendership Tournament First Round Match (15:20)