The April 25, 2008 Edition of Smackdown is a Professional wrestling television show of the WWE's Smackdown brand, it was taped on April 22, 2008 at the Greensboro Coliseum in Greensboro, North Carolina.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Dark Match: Funaki defeated Stu Sanders
- Dark Match: Chuck Palumbo defeated Funaki
- Shannon Moore (w/ Jimmy Wang Yang) defeated The Miz (w/ John Morrison) (4:35)
- Natalya (w/ Victoria) defeated Cherry (w/ Michelle McCool) (4:24)
- Edge defeated CM Punk (16:19)
- Vladimir Kozlov defeated Marty Garner (1:35)
- The Undertaker (c) defeated Batista in a No Disqualification Match to retain the WWE World Heavyweight Championship (13:26)
- WWE Smackdown #453 at CAGEMATCH.net
- [Smackdown #453 on WWE Network]