The April 21, 1991 edition of Wrestling Challenge is a Professional wrestling television show of the World Wrestling Federation. It was taped on March 27, 1991 at the Lawlor Events Center in Reno, Nevada.
- Numbers in parentheses indicate the length of the match.
- (c) refers to the champion(s) heading into the match.
- Jake Roberts defeated Barry O
- The Berzerker (w/ Mr. Fuji) defeated Randy Tyler
- Bret Hart defeated The Genius
- Tugboat defeated Jim Kolhep
- The Big Boss Man defeated Matthew Burns
- Mr. Perfect (w/ Bobby Heenan) (c) defeated Jerry Stevens to retain the WWF Intercontinental Championship